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Current Issue - November 2020, Volume 14, Issue No. 3

Official Journal of Malaysian Orthopaedic Association and ASEAN Orthopaedic Association

The Effect of Doxycycline on Achilles Tendon Repair in a Rat Model


  1. Lieberthal K, Paterson KL, Cook J, Kiss Z, Girdwood M, Bradshaw EJ. Prevalence and factors associated with asymptomatic Achilles tendon pathology in male distance runners. Phys Ther Sport. 2019; 39: 64-8. doi: 10.1016/j.ptsp.2019.06.006
  2. Lagas IF, Fokkema T, Verhaar JAN, Bierma-Zeinstra SMA, van Middelkoop M, de Vos RJ. Incidence of Achilles tendinopathy and associated risk factors in recreational runners: A large prospective cohort study. J Sci Med Sport. 2020; 23(5): 448-52. doi: 10.1016/j.jsams.2019.12.013
  3. Ochen Y, Beks RB, van Heijl M, Hietbrink F, Leenen LPH, van der Velde D, et al. Operative treatment versus nonoperative treatment of Achilles tendon ruptures: systematic review and meta-analysis. BMJ. 2019; 364: k5120. doi: 10.1136/bmj.k5120
  4. Lantto I, Heikkinen J, Flinkkila T, Ohtonen P, Leppilahti J. Epidemiology of Achilles Tendon Ruptures: Increasing Incidence over a 33-year Period. Scand J Med Sci Sports. 2015; 25(1): e133-e8. doi: 10.1111/sms.12253
  5. Cook JL, Khan KM, Purdam C. Achilles tendinopathy. Man Ther. 2002; 7(3): 121-30. doi: 10.1054/math.2002.0458
  6. Miao K, Jiang L, Zhou X, Wu L, Huang Y, Xu N, et al. Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear. Biosci Rep. 2019; 39(10): BSR20191549. doi: 10.1042/BSR20191549
  7. Gotoh M, Mitsui Y, Shibata H, Yamada T, Shirachi I, Nakama K, et al. Increased Matrix metalloprotease-3 Gene Expression in Ruptured Rotator Cuff Tendons is Associated with Postoperative Tendon Retear. Knee Surg Sports Traumatol Arthrosc. 2013; 21(8): 1807-12. doi: 10.1007/s00167-012-2209-x
  8. Dong M, Zhong L, Chen WQ, Ji XP, Zhang M, Zhao YX, et al. Doxycycline stabilizes vulnerable plaque via inhibiting matrix metalloproteinases and attenuating inflammation in rabbits. PloS One. 2012; 7(6): e39695. doi: 10.1371/journal.pone.0039695
  9. Yonemitsu R, Tokunaga T, Shukunami C, Ideo K, Arimura H, Karasugi T, et al. Fibroblast Growth Factor 2 Enhances Tendonto-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears. Am J Sport Med. 2019; 47(7): 1701-12. doi: 10.1177/0363546519836959
  10. Bedi A, Fox AJS, Kovacevic D, Deng XH, Warren RF, Rodeo SA. Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair. Am J Sports Med. 2010; 38(2): 308-17. doi: 10.1177/0363546509347366
  11. Pasternak B, Fellenius M, Aspenberg P. Doxycycline impairs tendon repair in rats. Acta Orthop Belg. 2006; 72(6): 756-60.
  12. Pasternak B, Missios A, Askendal A, Tengvall P, Aspenberg P. Doxycycline-coated Sutures Improve the Suture-Holding Capacity of the Rat Achilles tendon. Acta Orthop. 2007; 78(5): 680-6. doi: 10.1080/17453670710014392
  13. Nguyen QT, Norelli JB, Graver A, Ekstein C, Schwartz J, Chowdhury F, et al. Therapeutic effects of doxycycline on the quality of repaired and unrepaired Achilles tendons. Am J Sports Med. 2017; 45(12): 2872-81. doi: 10.1177/0363546517716637
  14. Hudek R, von Schacky C, Passow A, Abdelkawi AF, Werner B, Gohlke F. Degenerative rotator cuff tears are associated with a low Omega-3 Index. Prostaglandins Leukot Essent Fatty Acids. 2019; 148: 35-40. doi: 10.1016/j.plefa.2019.07.004.
  15. Treviño EA, McFaline-Figueroa J, Guldberg RE, Platt MO, Temenoff JS. Full-thickness rotator cuff tear in rat results in distinct temporal expression of multiple proteases in tendon, muscle, and cartilage. J Orthop Res. 2019; 37(2): 490-502. doi: 10.1002/jor.24179
  16. Kang X, Tian B, Zhang L, Ge Z, Zhao Y, Zhang Y. Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy. Sci Rep. 2019; 9(1): 17627. doi: 10.1038/s41598-019-54097-y
  17. Pasternak B, Schepull T, Eliasson P, Aspenberg P. Elevation of Systemic Matrix Metalloproteinases 2 and 7 and Tissue Inhibitor of Metalloproteinase 2 in Patients with a History of Achilles Tendon Rupture: Pilot Study. Br J Sports Med. 2010; 44(9): 669-72. doi: 10.1136/bjsm.2008.049411
  18. Sprangers S, Everts V. Molecular pathways of cell-mediated degradation of fibrillar collagen. Matrix Bio. 2019; 75: 190-200. doi: 10.1016/j.matbio.2017.11.008
  19. Kessler MW, Barr J, Greenwald R, Lane LB, Dines JS, Dines DM, et al. Enhancement of Achilles tendon repair mediated by matrix metalloproteinase inhibition via systemic administration of doxycycline. J Orthop Res. 2014; 32(4): 500-6. doi: 10.1002/jor.22564

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The Malaysian Orthopaedic Journal is a peer-reviewed journal that is published three times a year in both print and electronic online version. The purpose of this journal is to publish original research studies, evaluation of current practices and case reports in various subspecialties of orthopaedics and traumatology, as well as associated fields like basic science, biomedical engineering, rehabilitation medicine and nursing.

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