MOJ Header

Current Issue - March 2020, Volume 14, Issue No. 1

Official Journal of Malaysian Orthopaedic Association and ASEAN Orthopaedic Association

The Use of Alfa-Lipoic Acid-R (ALA-R) in Patients with Mild-Moderate Carpal Tunnel Syndrome: A Randomised Controlled Open Label Prospective Study

References

  1. Gelfman R, Melton LJ 3rd, Yawn BP, Wollan PC, Amadio PC, Stevens JC. Long-term trends in carpal tunnel syndrome. 2009; 72(1): 33-41. doi:10.1212/01.wnl.0000338533.88960.b9
  2. Shalimar A, Nor-Hazla MH, Arifaizad A, Jamari S. Splinting after Carpal Tunnel Release: Does it really Matter?. Malaysian Orthop J. 2015; 9(2): 41-6. doi:10.5704/MOJ.1507.011
  3. Atroshi I, Englund M, Turkiewicz A, Tagil M, Petersson IF. Incidence of physician-diagnosed carpal tunnel syndrome in the general population. Arch Intern Med. 2011; 171(10): 943-4. doi:10.1001/archinternmed.2011.203
  4. Pourmemari MH, Heliovaara M, Viikari-Juntura E, Shiri R. Carpal tunnel release: Lifetime prevalence, annual incidence, and risk factors. Muscle Nerve. 2018; 58(4): 497-502. doi:10.1002/mus.26145
  5. Tadjerbashi K, Akesson A, Atroshi I. Incidence of referred carpal tunnel syndrome and carpal tunnel release surgery in the general population: Increase over time and regional variations. J Orthop Surg (Hong Kong). 2019; 27(1): 2309499019825572. doi:10.1177/2309499019825572
  6. Wahab KW, Sanya EO, Adebayo PB, Babalola MO, Ibraheem HG. Carpal Tunnel Syndrome and Other Entrapment Neuropathies. Oman Med J. 2017; 32(6): 449-54. doi:10.5001/omj.2017.87
  7. Sharief F, Kanmani J, Kumar S. Risk factors, symptom severity and functional status among patients with carpel tunnel syndrome. Neurol India. 2018; 66(3): 743-6. doi:10.4103/0028-3886.232351
  8. Werner RA, Andary M. Carpal tunnel syndrome: pathophysiology and clinical neurophysiology. Clin Neurophysiol. 2002; 113(9): 1373-81.
  9. Verdugo RJ, Salinas RA, Castillo JL, Cea JG. Surgical versus non-surgical treatment for carpal tunnel syndrome. Cochrane database Syst Rev. 2008; (4): CD001552. doi:10.1002/14651858.CD001552.pub2
  10. Page MJ, O’Connor D, Pitt V, Massy-Westropp N. Exercise and mobilisation interventions for carpal tunnel syndrome. Cochrane database Syst Rev. 2012;(6): CD009899. doi:10.1002/14651858.CD009899
  11. Page MJ, Massy-Westropp N, O’Connor D, Pitt V. Splinting for carpal tunnel syndrome. Cochrane database Syst Rev. 2012; (7): CD010003. doi:10.1002/14651858.CD010003
  12. Page MJ, O’Connor D, Pitt V, Massy-Westropp N. Therapeutic ultrasound for carpal tunnel syndrome. Cochrane database Syst Rev. 2013; (3): CD009601. doi:10.1002/14651858.CD009601.pub2
  13. Rochette L, Ghibu S, Muresan A, Vergely C. Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. Can J Physiol Pharmacol. 2015; 93(12): 1021-7. doi:10.1139/cjpp-2014-0353
  14. Mrakic-Sposta S, Vezzoli A, Maderna L, Gregorini F, Montorsi M, Moretti S, et al. R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography. Oxid Med Cell Longev. 2018; 2018: 1767265. doi:10.1155/2018/1767265
  15. Pajardi G, Bortot P, Ponti V, Novelli C. Clinical usefulness of oral supplementation with alpha-lipoic Acid, curcumin phytosome, and B-group vitamins in patients with carpal tunnel syndrome undergoing surgical treatment. Evid Based Complement Alternat Med. 2014; 2014: 891310. doi:10.1155/2014/891310
  16. Di Geronimo G, Caccese AF, Caruso L, Soldati A, Passaretti U. Treatment of carpal tunnel syndrome with alpha-lipoic acid. Eur Rev Med Pharmacol Sci. 2009; 13(2): 133-9.
  17. Luchetti R, Tognon S , Cacciavillani M, Ronco S, Buzzelli N, Lanni G. Observational multicentric survey on carpal tunnel syndrome: demographic and clinical data from 34 Italian centers. Eur Rev Med Pharmacol Sci. 2017; 21(3): 460-9.
  18. Monroy-Guizar EA, Garcia-Benavides L, Ambriz-Plascencia AR, Pascoe-Gonzalez S, Totsuka-Sutto SE, Cardona-Munoz EG, et al. Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial. J Med Food. 2018; 21(5): 521-6. doi:10.1089/jmf.2017.0056
  19. Raddatz G, Bisswanger H. Receptor site and stereospecifity of dihydrolipoamide dehydrogenase for R- and S-lipoamide: a molecular modeling study. J Biotechnol. 1997; 58(2): 89-100.
  20. Padua L, LoMonaco M, Gregori B, Valente EM, Padua R, Tonali P. Neurophysiological classification and sensitivity in 500 carpal tunnel syndrome hands. Acta Neurol Scand. 1997; 96(4): 211-7.
  21. Boriani F, Granchi D, Roatti G, Merlini L, Sabattini T, Baldini N. Alpha-lipoic Acid After Median Nerve Decompression at the Carpal Tunnel: A Randomized Controlled Trial. J Hand Surg Am. 2017; 42(4): 236-42. doi:10.1016/j.jhsa.2017.01.011
  22. Chen PC, Chuang CH, Tu YK, Bai CH, Chen CF, Liaw MY. A Bayesian network meta-analysis: Comparing the clinical effectiveness of local corticosteroid injections using different treatment strategies for carpal tunnel syndrome. BMC Musculoskelet Disord. 2015; 16: 363. doi:10.1186/s12891-015-0815-8
  23. O’Connor D, Marshall S, Massy-Westropp N. Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome. Cochrane Database Syst Rev. 2003; (1): CD003219. doi:10.1002/14651858.CD003219
  24. Burton CL, Chesterton LS, Chen Y, van der Windt DA. Clinical Course and Prognostic Factors in Conservatively Managed Carpal Tunnel Syndrome: A Systematic Review. Arch Phys Med Rehabil. 2016; 97(5): 836-52.e1. doi:10.1016/j.apmr.2015.09.013
  25. Huisstede BM, Friden J, Coert JH, Hoogvliet P. Carpal tunnel syndrome: hand surgeons, hand therapists, and physical medicine and rehabilitation physicians agree on a multidisciplinary treatment guideline-results from the European HANDGUIDE Study. Arch Phys Med Rehabil. 2014; 95(12): 2253-63. doi:10.1016/j.apmr.2014.06.022
  26. Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. 2001; 17(10): 888-95.
  27. Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L. The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects. Altern Med Rev. 2007; 12(4): 343-51.
  28. Amenta F, Traini E, Tomassoni D, Mignini F. Pharmacokinetics of different formulations of tioctic (alpha-lipoic) acid in healthy volunteers. Clin Exp Hypertens. 2008; 30(8): 767-75. doi:10.1080/10641960802563568
  29. Breithaupt-Grogler K, Niebch G, Schneider E, Erb K, Hermann R, Blume HH, et al. Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci. 1999; 8(1): 57-65.
  30. Teichert J, Kern J, Tritschler HJ, Ulrich H, Preiss R. Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int J Clin Pharmacol Ther. 1998; 36(12): 625-8.
  31. Gleiter CH, Schug BS, Hermann R, Elze M, Blume HH, Gundert-Remy U. Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur J Clin Pharmacol. 1996; 50(6): 513-514.
  32. Keir PJ, Rempel DM. Pathomechanics of peripheral nerve loading. Evidence in carpal tunnel syndrome. J Hand Ther. 2005; 18(2): 259-269. doi:10.1197/j.jht.2005.02.001

Abstract   |   Reference

MOJ footer

About Us

The Malaysian Orthopaedic Journal is a peer-reviewed journal that is published three times a year in both print and electronic online version. The purpose of this journal is to publish original research studies, evaluation of current practices and case reports in various subspecialties of orthopaedics and traumatology, as well as associated fields like basic science, biomedical engineering, rehabilitation medicine and nursing.

Keep in Touch

creative-commons License