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Current Issue - March 2023, Volume 17, Issue No. 1

Official Journal of Malaysian Orthopaedic Association and ASEAN Orthopaedic Association

The Efficacy of Bisphosphonate in the Treatment of Giant Cell Tumour of the Bone: A Systematic Review and Meta-Analysis


  1. Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, et al. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008; 134(9): 969-78. doi: 10.1007/s00432-008-0370-x
  2. Singaravadivelu V, Kavinkumar V. Giant Cell Tumour Around Knee Managed by Curettage and Zoledronic Acid with Structural Support by Fibula Cortical Struts. Malays Orthop J. 2020; 14(3): 42-9. doi: 10.5704/MOJ.2011.008
  3. Tse LF, Wong KC, Kumta SM, Huang L, Chow TC, Griffith JF. Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control study. Bone. 2008; 42(1): 68-73. doi: 10.1016/j.bone.2007.08.038
  4. Dubey S, Rastogi S, Sampath V, Khan SA, Kumar A. Role of intravenous zoledronic acid in management of giant cell tumor of bone- A prospective, randomized, clinical, radiological and electron microscopic analysis. J Clin Orthop Trauma. 2019; 10(6): 1021-6. doi: 10.1016/j.jcot.2019.09.011
  5. Zhang W, Zhang Y, Li P, Rhodesm SD, Wang Y, Xue X, et al. Administration of sodium ibandronate in the treatment of complicated giant cell tumor of the spine. Spine (Phila Pa 1976). 2011; 36(17): E1166-72. doi: 10.1097/BRS.0b013e3182127f91
  6. Chang SS, Suratwala SJ, Jung KM, Doppelt JD, Zhang HZ, Blaine TA, et al. Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis. Clin Orthop Relat Res. 2004; (426): 103-9. doi: 10.1097/01.blo.0000141372.54456.80
  7. Gouin F, Rochwerger AR, Di Marco A, Rosset P, Bonnevialle P, Fiorenza F, et al. Adjuvant treatment with zoledronic acid after extensive curettage for giant cell tumours of bone. Eur J Cancer. 2014; 50(14): 2425-31. doi: 10.1016/j.ejca.2014.06.003
  8. Goldschlager T, Dea N, Boyd M, Reynolds J, Patel S, Rhines LD, et al. Giant cell tumors of the spine: has denosumab changed the treatment paradigm? J Neurosurg Spine. 2015; 22(5): 526-33. doi: 10.3171/2014.10.SPINE13937
  9. Lau CP, Huang L, Wong KC, Kumta SM. Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone. Connect Tissue Res. 2013; 54(6): 439-49. doi: 10.3109/03008207.2013.848202
  10. Lipplaa A, Kroep JR, van der Heijden L, Jutte PC, Hogendoorn PCW, Dijkstra S, et al. Adjuvant Zoledronic Acid in High-Risk Giant Cell Tumor of Bone: A Multicenter Randomized Phase II Trial. Oncologist. 2019; 24(7): 889-e421. doi: 10.1634/theoncologist.2019-0280
  11. Xu W, Wang Y, Wang J, Yang X, Liu W, Zhou W, et al. Long-term administration of bisphosphonate to reduce local recurrence of sacral giant cell tumor after nerve-sparing surgery. J Neurosurg Spine. 2017; 26(6): 716-21. doi: 10.3171/2016.10.SPINE151197
  12. Cheng YY, Huang L, Lee KM, Xu JK, Zheng MH, Kumta SM. Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone. Calcif Tissue Int. 2004; 75(1): 71-7. doi: 10.1007/s00223-004-0120-2

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The Malaysian Orthopaedic Journal is a peer-reviewed journal that is published three times a year in both print and electronic online version. The purpose of this journal is to publish original research studies, evaluation of current practices and case reports in various subspecialties of orthopaedics and traumatology, as well as associated fields like basic science, biomedical engineering, rehabilitation medicine and nursing.

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