Effectiveness of Platelet-Rich Plasma versus Intra-articular Steroid Injections in Advanced Knee Osteoarthritis – A Prospective Observational Study from Eastern India
References
- Gill TK, Mittinty MM, March LM, Steinmetz JD, Culbreth GT, Cross M, et al. Global, regional, and national burden of other musculoskeletal disorders, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023; 5(11): e670-e682. doi: 10.1016/S2665-9913(23)00232-1
- Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019; 393(10182): 1745-59. doi: 10.1016/S0140-6736(19)30417-9
- Arroll B, Goodyear-Smith F. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. BMJ. 2004; 328(7444): 869. doi: 10.1136/bmj.38039.573970.7C
- Crowley JL, Soti V. Platelet-Rich Plasma Therapy: An Effective Approach for Managing Knee Osteoarthritis. Cureus. 2023; 15(12): e50774. doi: 10.7759/cureus.50774
- Saita Y, Kobayashi Y, Uchino S, Nishio H, Wakayama T, Fukusato S, et al. Platelet-rich plasma therapy for knee osteoarthritis: Insights from real-world clinical data in Japan. Regen Ther. 2025; 29: 427-34. doi: 10.1016/j.reth.2025.04.002
- Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol. 2013; 9(12): 721-30. doi: 10.1038/nrrheum.2013.141
- Cole BJ, Karas V, Hussey K, Pilz K, Fortier LA. Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis. Am J Sports Med. 2017; 45(2): 339-46. doi: 10.1177/0363546516665809
- Di Martino A, Di Matteo B, Papio T, Tentoni F, Selleri F, Cenacchi A, et al. Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial. Am J Sports Med. 2019; 47(2): 347-54. doi: 10.1177/0363546518814532
- Wehling P, Evans C, Wehling J, Maixner W. Effectiveness of intra-articular therapies in osteoarthritis: a literature review. Ther Adv Musculoskelet Dis. 2017; 9(8): 183-196. doi: 10.1177/1759720X17712695
- Pal CP, Singh P, Chaturvedi S, Pruthi KK, Vij A. Epidemiology of knee osteoarthritis in India and related factors. Indian J Orthop. 2016; 50(5): 518-22. doi: 10.4103/0019-5413.189608
- Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988; 15(12): 1833-40.
- Habib GS. Systemic effects of intra-articular corticosteroids. Clin Rheumatol. 2009; 28(7): 749-56. doi: 10.1007/s10067-009-1135-x
- Shen L, Yuan T, Chen S, Xie X, Zhang C. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2017; 12(1): 16. doi: 10.1186/s13018-017-0521-3
- Pavlovic V, Ciric M, Jovanovic V, Stojanovic P. Platelet Rich Plasma: a short overview of certain bioactive components. Open Med (Wars). 2016; 11(1): 242-47. doi: 10.1515/med-2016-0048
- Anitua E, Sánchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007; 28(31): 4551-60. doi: 10.1016/j.biomaterials.2007.06.037
- Pretorius J, Nemat N, Alsayed A, Mustafa A, Hammad Y, Shaju T, et al. Double-Blind Randomized Controlled Trial Comparing Platelet-Rich Plasma With Intra-Articular Corticosteroid Injections in Patients With Bilateral Knee Osteoarthritis. Cureus. 2022; 14(9): e29744. doi: 10.7759/cureus.29744
- Idres FA, Samaan M. Intra-articular platelet-rich plasma vs. corticosteroid injections efficacy in knee osteoarthritis treatment: a systematic review. Ann Med Surg (Lond). 2023; 85(2): 102-10. doi: 10.1097/MS9.0000000000000106
- Irshad S, Waleed U, Zafar MH, Ramzan MT, Tariq MA, Hassan M, et al. The Efficacy of Intra-articular Platelet-Rich Plasma Injection Versus Corticosteroid Injection in the Treatment of Knee Osteoarthritis: A Prospective Comparative Analysis. Cureus. 2024; 16(5): e61040. doi: 10.7759/cureus.61040
- Boffa A, Moraca G, Sangiorgio A, Di Martino A, Bensa A, Filardo G. Corticosteroids versus platelet-rich plasma injections for knee osteoarthritis: Where is there more evidence? A systematic review of 60 years of literature. Knee. 2025; 55: 104-11. doi: 10.1016/j.knee.2025.03.010
- Dai WL, Zhou AG, Zhang H, Zhang J. Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthroscopy. 2017; 33(3): 659-70.e1. doi: 10.1016/j.arthro.2016.09.024
- Filardo G, Di Matteo B, Di Martino A, Merli ML, Cenacchi A, Fornasari P, et al. Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation: A Randomized Controlled Trial. Am J Sports Med. 2015 Jul;43(7):1575-82. doi: 10.1177/0363546515582027
- Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Cenacchi A, et al. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc. 2010; 18(4): 472-9. doi: 10.1007/s00167-009-0940-8
- Arroll B, Goodyear-Smith F. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. BMJ. 2004; 328: 869 doi:10.1136/bmj.38039.573970.7C
- Jüni P, Hari R, Rutjes AW, Fischer R, Silletta MG, Reichenbach S, da Costa BR. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015; 2015(10): CD005328. doi: 10.1002/14651858.CD005328.pub3
- Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020; 72(2): 149-62. doi: 10.1002/acr.24131
- Kon E, de Girolamo L, Laver L, Andriolo L, Andia I, Bastos R, et al. Platelet-rich plasma injections for the management of knee osteoarthritis: The ESSKA-ICRS consensus. Recommendations using the RAND/UCLA appropriateness method for different clinical scenarios. Knee Surg Sports Traumatol Arthrosc. 2024; 32(11): 2938-49. doi: 10.1002/ksa.12320
- Kon E, Di Matteo B, Delgado D, Cole BJ, Dorotei A, Dragoo JL, et al. Platelet-rich plasma for the treatment of knee osteoarthritis: an expert opinion and proposal for a novel classification and coding system. Expert Opin Biol Ther. 2020; 20(12): 1447-60. doi: 10.1080/14712598.2020.1798925
Abstract | Reference
