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Current Issue - November 2015, Volume 9, Issue No. 3

Official Journal of Malaysian Orthopaedic Association and ASEAN Orthopaedic Association

The Current Role of Stem Cells in Orthopaedic Surgery


  1. Mafi R, Hindocha S, Mafi P, Griffin M, Khan WS. Sources of adult mesenchymal stem cells applicable for musculoskeletal applications - a systematic  review of the literature. Open Orthop J. 2011; 5 Suppl 2: 242-8.
  2. Shostak S. (Re)defining stem cells. Bioessays. 2006; 28: 301-308.
  3. Shahriyari L, Komarova NL. Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer?  PLoS One. 2013; 8:e76195.
  4. Aldahmash A, Atteya M, Elsafadi M, Al-Nbaheen M, Al-Mubarak HA, Vishnubalaji R, et al. Teratoma formation in immunocompetent mice after syngeneic and allogeneic implantation of germline capable mouse embryonic stem cells. Asian Pac J Cancer Prev. 2013; 14: 5705-5711.
  5. Hernigou P, Poignard A, Manicom O, Mathieu G, Rouard H. The use of percutaneous autologous bone marrow transplantation in nonunion and  avascular necrosis of bone. J Bone Joint Surg Br. 2005; 87: 896-902.
  6. Pierini M, Di Bella C, Dozza B, Frisoni T, Martella E, Bellotti C, et al. The posterior iliac crest outperforms the anterior iliac crest when obtaining mesenchymal stem cells from bone marrow. J Bone Joint Surg Am. 2013; 95: 1101-1107.(Level IV)
  7. Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, et al. Clinical responses to bone marrow transplantation in children with severe  osteogenesis imperfecta. Blood. 2001; 97: 1227-31.(Level III)
  8. Giuliani N, Lisignoli G, Magnani M, Racano C, Bolzoni M, Dalla Palma B, et al. New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. Stem Cells Int. 2013; 2013: 312501.(Level V)
  9. Reichert JC, Cipitria A, Epari DR, Saifzadeh S, Krishnakanth P, Berner A, et al. A tissue engineering solution for segmental defect regeneration in load-bearing long bones. Sci Transl Med. 2012; 4: 141.
  10. Wright JG, Yandow S, Donaldson S, Marley L, Simple Bone Cyst Trial Group. A randomized clinical trial comparing intralesional bone marrow and steroid injections for simple bone cysts. J Bone Joint Surg Am. 2008; 90: 722-730.(Level I)
  11. Neen D, Noyes D, Shaw M, Gwilym S, Fairlie N, Birch N. Healos and bone marrow aspirate used for lumbar spine fusion: a case controlled study  comparing healos with autograft. Spine (Phila Pa 1976). 2006; 31: E636-40.(Level III)
  12. Gan Y, Dai K, Zhang P, Tang T, Zhu Z, Lu J. The clinical use of enriched bone marrow stem cells combined with porous betatricalcium phosphate in posterior spinal fusion. Biomaterials. 2008; 29: 3973-3982.(Level II/III)
  13. Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito H, Tsuji K, et al. Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. Arthritis Res Ther. 2010; 12: R206.
  14. Mesoblast. Intervertebral Disc Repair. Available at: intervertebral-disc-repair. Accessed May 1st, 2014.
  15. Park JH, Kim DY, Sung IY, Choi GH, Jeon MH, Kim KK, et al. Long-term results of spinal cord injury therapy using mesenchymal stem cells derived from bone marrow in humans. Neurosurgery. 2012; 70: 1238-47; discussion 1247.(Level IV)
  16. Tamaki T, Hirata M, Soeda S, Nakajima N, Saito K, Nakazato K, et al. Preferential and comprehensive reconstitution of severely damaged sciatic nerve using murine skeletal muscle-derived multipotent stem cells. PLoS One. 2014; 9: e91257.
  17. Nejadnik H, Hui JH, Feng Choong EP, Tai BC, Lee EH. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010; 38: 1110-1116.(Level III)
  18. Lozito TP, Tuan RS. Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs. J Cell Physiol. 2011; 226 385-396.
  19. Sato M, Uchida K, Nakajima H, Miyazaki T, Guerrero AR, Watanabe S, et al. Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis. Arthritis Res Ther. 2012; 14: R31.
  20. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008; 11: 343-353.(Level IV)
  21. Dallari D, Savarino L, Stagni C, Cenni E, Cenacchi A, Fornasari PM, et al. Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells. J Bone Joint Surg Am. 2007; 89: 2413- 2420.(Level I/II)
  22. Maclaine SE, McNamara LE, Bennett AJ, Dalby MJ, Meek RM. Developments in stem cells: implications for future joint replacements. Proc Inst Mech Eng H. 2013; 227: 275-83.(Level V)
  23. Rastogi S, Sankineani SR, Nag HL, Mohanty S, Shivanand G, Marimuthu K, et al. Intralesional autologous mesenchymal stem cells in management of osteonecrosis of femur: a preliminary study. Musculoskelet Surg. 2013; 97: 223-8.(Level III)
  24. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007; 25:2648-2659.
  25. Adams SB,Jr, Thorpe MA, Parks BG, Aghazarian G, Allen E, Schon LC. Stem cell-bearing suture improves Achilles tendon healing in a rat model. Foot Ankle Int. 2014; 35: 293-299.
  26. Pascual-Garrido C, Rolon A, Makino A. Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup. Stem  Cells Int. 2012; 2012: 953510.(Level IV)
  27. Planka L, Srnec R, Rauser P, Stary D, Filova E, Jancar J, et al. Nanotechnology and mesenchymal stem cells with chondrocytes in prevention of partial growth plate arrest in pigs. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012; 156: 128- 34.
  28. Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, et al. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass.  Nat Med. 2012; 18: 456-462.
  29.  Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, et al. Autologous transplantation of muscle-derived CD133+ stem cells in Duchenne muscle patients.  Cell Transplant. 2007; 16: 563-577.(Level IV)
  30. Clarke AW, Alyas F, Morris T, Robertson CJ, Bell J, Connell DA. Skin-derived tenocyte-like cells for the treatment of patellar tendinopathy. Am J Sports  Med. 2011; 39(3): 614-23. (Level I)
  31. Kim SJ, Shin YW, Yang KH, Kim SB, Yoo MJ, et al. A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron) injection to treat fractures. BMC Musculoskelet Disord. 2009; 10: 20. (Level II)
  32.  Sen RK, Tripathy SK, Aggarwal S, Marwaha N, Sharma RR, Khandelwal N. Early results of core decompression and autologous bone marrow mononuclear cells instillation in femoral head osteonecrosis: a randomized control study. J Arthroplasty. 2012; 27(5): 679-86. (Level II)
  33. Gangji V, De Maertelaer V, Hauzeur JP. Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral  head: Five year follow-up of a prospective controlled study. Bone. 2011; 49(5): 1005-9. (Level II)
  34. Dai G, Liu X, Zhang Z, Yang Z, Dai Y, Xu R. Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury. Brain Res. 2013; 1533: 73-9. (Level III)
  35. Buda R, Vannini F, Cavallo M, Grigolo B, Cenacchi A, Giannini S. Osteochondral lesions of the knee: a new one-step repair technique with bone- marrow-derived cells. J Bone Joint Surg Am. 2010; 92 Suppl 2:2-11. (Level III)
  36. Cristante AF, Barros-Filho TE, Tatsui N, Mendrone A, Caldas JG, Camargo A, Alexandre A, Teixeira WG, Oliveira RP, Marcon RM. Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients. Spinal Cord. 2009 Oct; 47(10): 733-8. (Level IV)
  37. Skowroński J, Skowroński R, Rutka M. Cartilage lesions of the knee treated with blood mesenchymal stem cells - results. Ortop Traumatol Rehabil. 2012; 14(6): 569-77. (Level IV)
  38. Connell D, Datir A, Alyas F, Curtis M. Treatment of lateral epicondylitis using skin-derived tenocyte-like cells. Br J Sports Med. 2009; 43(4): 293-8. (Level IV)
  39. Giannini S, Buda R, Vannini F, Cavallo M, Grigolo B. One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Clin Orthop Relat Res. 2009; 467(12): 3307-20. (Level IV)
  40. Jäger M, Jelinek EM, Wess KM, Scharfstädt A, Jacobson M, Kevy SV, Krauspe R. Bone marrow concentrate: a novel strategy for bone defect treatment. Curr Stem Cell Res Ther. 2009; 4(1): 34-43. (Level IV)

Abstract   |   Reference

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The Malaysian Orthopaedic Journal is a peer-reviewed journal that is published three times a year in both print and electronic online version. The purpose of this journal is to publish original research studies, evaluation of current practices and case reports in various subspecialties of orthopaedics and traumatology, as well as associated fields like basic science, biomedical engineering, rehabilitation medicine and nursing.

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